Adaptive Immunity and Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Innate and adaptive immunity in the pathogenesis of atherosclerosis.
This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive immunity, with its T cells, antibodies, and immunoregulatory cytokines, powerf...
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Epidemiological investigations clearly pointed out that hypertension is a powerful cardiovascular risk factor. Elevated blood pressure levels have been found to be highly predictive of cardiovascular events, including ischemic coronary disease, stroke, and peripheral arterial disease.1 These ischemic cardiovascular events have a predominant vascular origin resulting from atherosclerosis. Hypert...
متن کاملThe role of adaptive T cell immunity in atherosclerosis.
There is now solid evidence that T cell adaptive immunity is involved in atherogenesis. While initial studies have focused on the pathogenic arm of the immune response, more recent work clearly suggests an important role for several subsets of regulatory T cells in the protection against lesion development. Here, we review the current knowledge on the role of both pathogenic and regulatory adap...
متن کاملImmunity and Atherosclerosis
Atherosclerotic plaque formation is strongly influenced by different arms of the immune system, including B lymphocytes. B cells are divided into 2 main families: the B1 and the B2 cells. B1 cells are atheroprotective mainly via the production of natural IgM antibodies that bind oxidized low-density lipoprotein and apoptotic cells. B2 cells, which include follicular and marginal zone B cells, a...
متن کاملImmunity, atherosclerosis and cardiovascular disease
Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory condition with immune competent cells in lesions producing mainly pro-inflammatory cytokines. Dead cells and oxidized forms of low density lipoproteins (oxLDL) are abundant. The major direct cause of CVD appears to be rupture of atherosclerotic plaques. oxLDL has proinflammatory and immune-stimulatory pr...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2013
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2012.10.006